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Synthesis of novel 1H-imidazo-[4,5-c]quinolin-4-amine derivatives with structural variation at the 2 position.a
a Reagents: (i) polyphosphoric acid, R1CO2H; (ii) m-CPBA, CHCl3/CH2Cl2/MeOH; (iii) POCl3, toluene/DMF; (iv) R2-PhNH2, DMF; (v) LiAlH4, THF; vi) MeNH2, EtOH; (vii) H2/Pd, MeOH.
