Table 4.

Least Squares Mean Comparisons of Bone Outcomes with Daily Fluoride Intake (mg) (adjusted for Age, Tanner stage, Height and Weight) for Girls

Dependent Variable	Pr > F	1 Lowest Tertile	2 Middle Tertile	3 Highest Tertile	l vs. 2 (p-value)	1 vs. 3 (p-value)	2 vs. 3 (p-value)
Fluoride AUC 0–3 yrs, mg/d
BMC hip (g)	0.64	18.86	18.63	18.45	0.60	0.35	0.69
BMC spine (g)	0.37	31.76	31.30	32.50	0.60	0.39	0.16
BMC whole body without head (g)	0.67	1053.75	1038.43	1051.14	0.41	0.89	0.49
BMD hip (g/(cm2)	0.45	0.74	0.74	0.73	0.52	0.21	0.54
BMD spine (g/(cm2)	0.64	0.73	0.71	0.73	0.45	0.94	0.39
Fluoride AUC 3–6 yrs, mg/d
BMC hip (g)	0.02	19.20	18.20	18.06	0.02	0.01	0.74
BMC spine (g)	0.43	32.47	31.46	31.51	0.25	0.27	0.96
BMC whole body without head (g)	0.03	1072.95	1028.35	1029.65	0.02	0.02	0.95
BMD hip (g/(cm2)	0.04	0.75	0.72	0.73	0.01	0.11	0.31
BMD spine (g/(cm2)	0.26	0.74	0.71	0.72	0.15	0.17	0.92
Fluoride AUC 0–8.5 yrs, mg/d
BMC hip (g)	0.03	19.17	18.56	17.94	0.18	0.01	0.16
BMC spine (g)	0.85	32.02	31.50	31.86	0.57	0.86	0.70
BMC whole body without head (g)	0.06	1070.20	1038.65	1026.72	0.10	0.02	0.53
BMD hip (g/(cm2)	0.07	0.75	0.72	0.72	0.05	0.04	0.96
BMD spine (g/(cm2)	0.40	0.73	0.71	0.72	0.22	0.27	0.88
Fluoride AUC 0–11 yrs, mg/d
BMC hip (g)	0.03	18.79	18.96	17.80	0.71	0.03	0.01
BMC spine (g)	0.69	31.32	32.12	31.78	0.39	0.62	0.72
BMC whole body without head	0.05	1061.50	1049.94	1016.46	0.55	0.02	0.08
BMD hip (g/(cm2)	0.29	0.74	0.73	0.72	0.41	0.12	0.46
BMD spine (g/(cm2)	0.89	0.72	0.72	0.72	0.99	0.69	0.68

Pr>F is the p-value from the overall test of the null hypothesis of no mean difference among the three tertiles.

P-values for pair-wise comparisons are reported without adjustment for multiple comparisons.