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. Author manuscript; available in PMC: 2009 Oct 22.
Published in final edited form as: Crit Care Med. 2007 Oct;35(10):2243–2250. doi: 10.1097/01.ccm.0000280434.33451.87

Table 5.

Bivariate and multivariate analysis of baseline biomarker levels in patients with acute lung injury

Biomarker, Day 0 n Median Value, Trauma Median Value, Nontrauma Unadjusted p Value Multivariable p Value
ICAM-1, ng/mL 1307 410 (272–738) 765 (480–1223) <.001 <.001
SP-D, ng/mL 1075 58 (37–94) 95 (45–211) <.001 .001
Protein C, % of control 1308 58 (45–78) 53 (35–84) .07 .14
vWF, % of control 1088 226 (142–331) 355 (215–551) <.001 <.001
PAI-1, ng/mL 1304 56 (36–104) 70 (37–157) .045 .95
IL-6, pg/mL 1302 300 (128–674) 259 (100–850) .44 .047
IL-8, pg/mL 1309 21 (20–59) 44 (20–103) .002 .30
sTNFr-1, pg/mL 1091 2535 (1945–3332) 3748 (2340–7661) <.001 .004

ICAM, intercellular adhesion molecule; SP-D, surfactant protein D; vWF, von Willebrand factor antigen; PAI, plasminogen activator inhibitor; IL, interleukin; sTNFr, soluble tumor necrosis factor receptor.

All biomarker values represent median (interquartile range) with bivariate comparison using Mann-Whitney U test. Multivariable linear model (using natural log-transformed biomarker levels) controls for age, gender, ethnicity, presence of significant comorbidities (acquired immunodeficiency syndrome, immunosuppression, diabetes, and end-stage renal disease), severity of injury, and Pao2/Fio2 ratio.