Table 2.

Tead2-Dependent Exencephaly

	Tead2+/−	Tead2−/−	Total
(A) ♂ Tead2+/− X ♀Tead2−/−
Total mice	27	27	54
Exencephalic mice	2	8	10
% Exencephalic	7	30	19
(B) ♂ Tead2−/− X ♀ Tead2+/−
Total mice	30	22	52
Exencephalic mice	0	2	2
% Exencephalic	0	9	4

(A) Tead2 nullizygous females were mated with heterozygous males, and embryos at E11.5 to E17.5 were examined for neural tube defects and genotyped. Results from seven litters were combined. (B) Tead2 nullizygous males were mated with heterozygous females, and postimplantation stage embryos were examined for NTDs and genotyped. Results from six litters were combined. The difference between “% Execenphalic (Total)” in panels A and B was statistically significant (P < 0.02). The data were analyzed by testing the difference in proportions using normal approximation to the binomial.