. Author manuscript; available in PMC: 2009 Nov 1.

Published in final edited form as: Cancer Gene Ther. 2008 Dec 26;16(5):405–414. doi: 10.1038/cgt.2008.99

kg)^a.

Parameter	DTX	DTX + AdlacZ	DTX + Adp53
AUC (ng/ml/h)	1,496.14 ± 281.62	2,987.37 ± 197.97^*	2,113.44 ± 197.01
CL (L/h/kg)	7.35 ± 1.22	3.38 ± 0.22^*	4.85 ± 0.43
Vss (L/kg)	17.43 ± 2.80	6.05 ± 0.67^*	17.68 ± 2.54
t_1/2 (h)	1.98 ± 0.10	5.06 ± 0.37^*	5.55 ± 0.84^*

Data were obtained from plasma samples and reflect average values + standard errors of the means from 4-5 animals per treatment group.

p ≤ 0.05.

AUC: area under plasma concentration-time curve extrapolated to infinity, CL: systemic clearance, Vss: volume of distribution at steady state, t_1/2: terminal elimination half-life.

Table 1. Calculated Pharmacokinetic Parameters of DTX (10 mg/kg) Alone or in Combination with Recombinant Adenovirus (5 × 1011 vp/kg)a.

Table 1. Calculated Pharmacokinetic Parameters of DTX (10 mg/kg) Alone or in Combination with Recombinant Adenovirus (5 × 10¹¹ vp/kg)^a.