. Author manuscript; available in PMC: 2010 Nov 2.

Published in final edited form as: DNA Repair (Amst). 2009 Sep 1;8(11):1273–1282. doi: 10.1016/j.dnarep.2009.08.003

Tabel 1.

Addition of MX to Oxidizing Agents Results in a Decrease in Cell Survival in differentiated SH-SY5Y cells

Oxidizing agent	MX 0mM	MX 1mM	Mx 2mM	MX 5mM	MX 10mM
H₂O₂ (uM) LD₅₀	220 ± 7		125 ± 2^*	112 ± 2^*^#	85 ± 4^*^#
^§menadiones (uM) LD₈₀	44 ± 3		36 ± 2^*	36 ± 2^*	36 ± 1^*
XO (mU/ml)/HX LD₅₀	17 ± 3	4 ± 0.2^*	2.4 ± 0.1^*^#	1.6 ± 0.2^*^#

Note: The values are LD₅₀ of H₂O₂ and XO/HX and LD₈₀ of menadione or without MX treatment for 24hrs (n=3).

Abbreviations: H₂O₂, hydrogen peroxide; XO, Xanthine Oxidase; HX, hypoxanthine; MX, methoxyamine.

P< 0.05, all compared each +/− MX to oxidant alone at LD₅₀ dose.

P< 0.05, all compared each + higher dose MX to oxidant + lower MX dose at LD₅₀ dose.

^§

LD₈₀menadione