AZM. (a) The 2|F
o| − |F
c| electron-density map (blue) for the active-site AZM 701, contoured at 2.2σ. (b) Semi-transparent surface of CA II, showing the locations of the three AZMs. AZM–CA II interactions are shown in (c) for AZM 701 (active site), (d) for AZM 702 and (e) for AZM 703. Protein C atoms are coloured gray, symmetry-related protein C atoms mauve, ligand C atoms yellow, N atoms blue, O atoms red, S atoms orange and Zn atoms purple. Waters are represented by red spheres. This figure was created using PyMOL (DeLano, 2002 ▶).