Table 3.

PR interval and Risks of Death, Atrial Fibrillation, and Pacemaker Implantation

	Whole Sample Hazards Ratio (95% Confidence Interval)				Persons Not on Nodal-Blocking Agents Hazards Ratio (95% Confidence Interval)
Endpoint	Unadjusted	P-value	Multivariable- adjusted	P-value	Unadjusted	P-value	Multivariable- adjusted	P-value
Atrial fibrillation	1.38	<0.001	1.12	0.02	1.39	<0.001	1.12	0.02
	(1.27–1.50)		(1.02–1.22)		(1.28–1.52)		(1.02–1.23)
Pacemaker implantation	1.43	<0.001	1.22	<0.001	1.88	<0.001	1.37	<0.001
	(1.37–1.50)		(1.14–1.30)		(1.68–2.09)		(1.20–1.57)
Death	1.27	<0.001	1.08	0.005	1.27	<0.001	1.08	0.008
	(1.22–1.33)		(1.02–1.13)		(1.21–1.34)		(1.02–1.14)

Number of events in the sample included 481 for AF, 124 for pacemaker implantation, and 1,739 for death. Hazards ratios represent risk per SD increment in PR interval. Values in parentheses are 95% confidence intervals. All models are stratified by sex and cardiovascular disease status, and further adjusted for age, heart rate, body mass index, hypertension, smoking, diabetes, and total/HDL cholesterol. For AF analyses, additional covariates included atrial premature beats, valve disease, ECG LVH. For pacemaker analyses, QRS duration was included as an additional covariate.