FIG. 6.

(A) Model depicting the repression of ANK expression in hypoxia. We hypothesize that elevated expression of HIF-1 in hypoxia upregulates the expression of some repressor gene whose protein product is able to repress the expression of ANK in hypoxic conditions. A possible candidate gene(s) for this repressor is DEC1 and/or DEC2. (B) Relative expression of DEC1 and DEC2 in N1511 cells in hypoxia and normoxia showing that these transcripts are highly expressed in hypoxic conditions in the chondrocytic cells used in these studies. n = 3; *p < 0.05 with respect to expression of DEC1 and DEC2 in hypoxia vs. normoxia.