Table 1.

Binding site patterns used for evaluation

	Brief description
PS00219	PROSITE pattern for the anion exchanger family (PDOC00192)
PS00063	PROSITE pattern for the aldo-keto reductase family (PDOC00061). Family binds Nicotinamide-Adenine-Dinucleotide Phosphate (NAP).
PS00307	Pattern created by extension of PROSITE pattern which is a legume lectin beta-chain signature (PDOC00278). Family binds calcium and manganese located in the C-terminal section of the beta-chain.
MPI phosphatase	Pattern created by selecting the fragment which interacts with sulphate ions (SO4) from the PROSITE profile for Rhodanese domain (PS50206) which is present in M-phase inducer (MPI) phosphatase family.
Zinc finger	Zinc finger meta-pattern created using 7 different PROSITE zinc finger patterns: PS00028, PS00518, PS00752, PS01030, PS01102, PS13000 and PS01358.