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. 2009 Oct 2;9:350. doi: 10.1186/1471-2407-9-350

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Copyright ©2009 Kaul-Ghanekar et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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SMAR1 overexpression results into increased cytoskeletal volume. AFM images of cellular cytoskeleton of HEK 293 control cells as well as those treated with SMAR1-P44 peptide. Height images of a group of cells (A) and a single cell (B) are shown whose 3D (C) is also depicted. Height (D) and profile (E) images of a zoomed area within the single cell are shown in both control and SMAR1-P44 treated cells. Using flooding/find hills option of free software WSxM (to calculate the volume of the cellular cytoskeleton), the zoomed image showing the volume of cytoskeleton (F) is more in SMAR1-P44 treated cells than the control cells.