TABLE 3.

TGFB3 maternal and fetal genotypes and risk of PIH

	Maternal				Fetal
TGFB3 locus	N(%)		OR (95% Cl)		N(%)		OR (95% Cl)
	Controls	Cases	Adjusted*	Multl-locus Adj**	Controls	Cases	Adjusted*	MUltl-locus Adj**
rs114664142
CC	136 (81%)	105 (81%)	1.00 (ref)	1.00 (ref)	129 (77%)	109 (85%)	1.00 (ref)	1.00 (ref)
CT/TT	31 (19%)	24 (19%)	1.66 (0.75, 3.65)	1.68 (0.74, 3.85)	38 (23%)	20 (16%)	0.34 (0.15, 0.77)	0.32 (0.14, 0.77)
rs2205181
CC	42 (25%)	30 (23%)	1.00 (ref)	1.00 (ref)	45 (27%)	37 (29%)	1.00 (ref)	1.00 (ref)
TC	85 (51%)	72 (56%)	1.11 (0.57, 2.14)	1.34 (0.65, 2.79)	86 (52%)	64 (50%)	0.87 (0.46, 1.65)	1.17 (0.58, 2.34)
TT	40 (24%)	27 (21%)	0.99 (0.43, 2.26)	1.29 (0.48, 3.49)	36 (22%)	28 (22%)	0.87 (0.39, 1.94)	1.33 (0.53, 3.36)
rs2268624
GG	110 (66%)	79 (61%)	1.00 (ref)	1.00 (ref)	112 (67%)	81 (63%)	1.00 (ref)	1.00 (ref)
GC/CC	57 (34%)	50 (39%)	1.24 (0.74, 2.10)	1.27 (0.67, 2.40)	55 (33%)	48 (37%)	0.91 (0.52, 1.61)	1.28 (0.68, 2.41)
rs3917200
GG	146 (87%)	108 (84%)	1.00 (ref)	1.00 (ref)	142 (85%)	103 (80%)	1.00 (ref)	1.00 (ref)
GA/AA	21 (13%)	21 (16%)	1.14 (0.65, 2.01)	1.66 (0.68, 4.01)	25 (15%)	26 (20%)	1.28 (0.72, 2.26)	1.33 (0.60, 2.97)
Total	167 (100%)	129 (100%)			167 (100%)	129 (100%)

^*Adjusted for maternal age (<29 vs. ≥29 years), gestational age (<37, 37, 38, 39, ≥40 weeks), parity (nulliparous vs. parous), and fetal (or maternal) genotype at the same locus

^**Further adjusted for maternal and fetal genotypes at all other loci