Table 1.

Systemic and cardiac function and myocardial microvascular density (mean±SEM) assessed by micro-CT in normal, hypertension (HTN), and HTN+bindarit pigs.

	Normal n=6	HTN n=6	HTN+bindarit n=6
Mean arterial pressure (mmHg)	101±4	120±5*	124±9*
Change post-adenosine (%)	-6±1#	-14±5#	-17±2*#
Heart Rate (bpm)	75±7	67±4	74±3
Plasma Renin Activity (ng/ml/hour)	0.17±0.03	0.17±0.02	0.16±0.06
Systemic Aldosterone (pg/ml)	684±68	1194±156*	971±139*
Endothelin-1 (pg/ml)	5.6±0.2	7.9±0.8*	5.9±0.3†
Stroke Volume (ml)	54±5	46±3	47±5
Cardiac Output (Liter/min)	3.5±0.4	2.8±0.1	3.4±0.5
E/A Ratio	1.98±0.17	1.04±0.10*	1.47±0.15†
LV Muscle Mass / Body Weight (g/kg)	2.14±0.16	3.43±0.16*	2.79±0.16*†

^*p<0.05 vs. normal;

^†p<0.05 vs. HTN;

^#p<0.05 vs. baseline

MAP: mean arterial pressure; LV: left ventricle