Table 3.
Baseline | Week 1 | Week 2 | Week 3 | Week 4 | |
---|---|---|---|---|---|
(A) sCD40L levels over 4 weeks after clopidogrel cessation | |||||
CD40L | |||||
Median | 224 | 298 | 285.5 | 292 | 324.5 |
Max | 1450 | 2483 | 2559 | 2871 | 2474 |
Min | 10 | 36 | 23 | 42 | 18 |
Q3 | 364.5 | 478 | 569.5 | 509 | 541 |
Q1 | 129.5 | 161 | 160.75 | 155 | 199.5 |
Upper limit of normal | 0 pg/ml | ||||
Lower limit of normal | 5000 pg/nl | ||||
Average | 310.2 | 434.9 | 469.1 | 412.9 | 446.1 |
Std | 282.3 | 453.8 | 483.7 | 431.3 | 409.5 |
Mean percent change from baseline + SE | 35% + 10% | 39% + 11% | 33% + 10% | 39% + 11% | |
P < 0.001 | P < 0.001 | P < 0.001 | P < 0.001 | ||
(B) P-selectin levels over 4 weeks after clopidogrel cessation | |||||
P-selectin | |||||
Median | 44 | 49 | 50 | 45.5 | 45 |
Max | 104 | 114 | 138 | 147 | 150 |
Min | 20 | 22 | 9 | 17 | 23 |
Q3 | 58 | 60.25 | 60.25 | 59 | 55.25 |
Q1 | 37 | 40 | 39 | 35 | 35 |
Upper limit of normal | 51 ng/ml | ||||
Lower limit of normal | 113 ng/ml | ||||
Mean | 47.2 | 51.3 | 51.7 | 49.2 | 48.1 |
Std | 16.2 | 17.2 | 18.7 | 20.1 | 20.3 |
Mean percent change from baseline + SE | 9% + 2% | 11% + 2% | 4% + 3% | 2% + 3% | |
P < 0.001 | P < 0.001 | P = 0.173 | P = 0.488 | ||
(C) Levels of CRP over 4 weeks after clopidogrel cessation | |||||
hsCRP (mg/L) | |||||
Median | 1.59 | 1.25 | 1.1 | 1.11 | 1.22 |
Min | 0.1 | 0.1 | 0.2 | 0.2 | 0.1 |
Max | 57.9 | 27.7 | 15.6 | 62.9 | 19.5 |
Q3 | 3.70 | 2.61 | 3.46 | 3.29 | 2.83 |
Q1 | 0.74 | 0.72 | 0.66 | 0.62 | 0.61 |
Average | 3.92 | 2.39 | 2.33 | 2.87 | 2.76 |
Std | 7.73 | 3.60 | 2.63 | 6.70 | 3.96 |
Lower limit of normal | 0 mg/L | ||||
Upper limit of normal | 11 mg/L | ||||
Mean percent change from baseline + SE | −21% + 7% | −23% + 7% | −19.% + 8% | −18% + 8% | |
P = 0.008 | P = 0.004 | P = 0.038 | P = 0.062 |