. Author manuscript; available in PMC: 2009 Oct 23.

Published in final edited form as: Hepatology. 2009 Jan;49(1):306–317. doi: 10.1002/hep.22603

Table 4. Selected studies of metformin in patients with NAFLD.

Author (ref)	N	Design	Comparator	Population	Duration	Liver enzymes	Histology
Marchesini et al¹⁴²	14	Open label Single arm	None	Adults Mostly non-diabetic	4 mo	Improved	Not evaluated
Nair et al¹⁴³	15	Open label Single arm	None	Non-diabetics	12 mo	Improved	Improved inflammation
Uygun et al¹⁴⁴	36	Open label	Calorie restricted diet	Non-diabetics	6 mo	Improved	Improved inflammation
Bugianesi et al¹⁴⁵	55	Randomized clinical trial	Calorie restricted diet	Non-diabetics	12 mo	Improved	Improved steatosis, inflammation and fibrosis
Schwimmer et al¹⁴⁶	10	Open label Single arm	None	Non-diabetics	6 mo	Improved	Not evaluated
Loomba et al¹⁴⁷	14	Open label Single arm	None	Non-diabetics	48 wks	Improved	Improved steatosis and inflammation
Nobili et al¹⁴⁸	57	Open label	Antioxidant	Non-diabetics	24 months	No difference	No difference