Figure 1.
Predicted total horizontal activity counts in male and female periadolescent rats following repeated saline (SAL) or lobeline (LOB; 1.0–10 mg/kg) injection. Rats exhibited tolerance to the repeated effects of LOB and females developed tolerance to repeated LOB 5.6 mg/kg at a slower rate than males (p<0.01). n = 10–12 animals/group.