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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Pharmacol Biochem Behav. 2009 Sep 17;94(2):296–304. doi: 10.1016/j.pbb.2009.09.009

Figure 3.

Figure 3

Total horizontal counts (A) and center distance travelled (B) during saline (SAL) baseline (open circles) and SAL challenge (filled circles) in animals repeatedly treated with lobeline (LOB) 1.0, 3.0, 5.6, or 10 mg/kg during the seven-day treatment phase of the experiment. The SAL Baseline occurred one day prior to the first day of LOB or saline control injection. SAL Challenge was administered one day after the seventh LOB or SAL injection. Multiple regression analyses, which were performed on the percent of SAL control animal’s data, demonstrate that the dose-dependent response was characterized as a linear trend for both the total horizontal activity [day × dose: F (1, 86) = 15.8, p = 0.0001], and center distance travelled data [day × dose: F (1, 86) = 14.8, p = 0.0001]. The data represent the first 20 minutes of the activity session. The dotted lines represent 95% confidence intervals. n = 20–24 animals/dose.