Effects of rat ghrelin (A) and gastrin-17 (B) on acid output in gastric lumen-perfused rats. A: Time course of acid output by IV administration of ghrelin (0.04, 0.8, 4, 20 μg/kg) in gastric lumen perfused rats; B: Time course of acid output by IV administration of gastrin (0.8, 8, 13.2 and 20 μg/kg) in gastric lumen perfused rats. Saline was administered in control rats. Each value represents the mean ± SE of acid output at 15 min intervals. n = 4, 5, 6, 7. Reprinted with permission[30].