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. Author manuscript; available in PMC: 2009 Oct 23.
Published in final edited form as: Curr Med Chem. 2008;15(28):2921–2932. doi: 10.2174/092986708786848703

Fig. (1). Pathways for nicotine degradation.

Fig. (1)

Once absorbed in the bloodstream nicotine is degraded, in the liver, by a variety of enzymatic pathway to give rise to identifiable and measurable reaction products. Abbreviations: CYP2A6 - cytochrome P450 2A6; AOX – Aldehyde oxidase; UGT1 – UDP-glucuronosyltransferase; t’-3’-HC – 3’-hydroxy cotinine.