Table 5. Primary Causes of Graft Loss after 10 Years, by Interval Posttransplant and Donor Source (Primary Transplant Recipients).
10 through 14 years | 15 through 19 years | 20 through 24 years | ||||
---|---|---|---|---|---|---|
DD
(n=205) |
LD
(n=267) |
DD
(n=81) |
LD
(n=131) |
DD
(n=29) |
LD
(n=65) |
|
Acute rejection (AR), n (%) | 2 (1%) | 4 (2%) | -- | 1 (1%) | -- | -- |
Chronic rejection (CAN), n (%) | 57 (28%) | 78 (29%) | 19 (23%) | 32 (24%) | 12 (43%) | 11 (17%) |
Death with function, n (%) | 112 (55%) | 130 (49%) | 43 (53%) | 68 (52%) | 14 (50%) | 38 (58%) |
Recurrent disease, n (%) | 6 (3%) | 21 (8%) | 3 (4%) | 8 (6%) | -- | 3 (5%) |
De novo disease, n (%) | 1 (.5%) | -- | 1 (1%) | -- | 1 (4%) | -- |
Noncompliance, n (%) | 4 (2%) | 9 (3%) | 1 (1%) | 3 (2%) | -- | 3 (5%) |
CNI-toxicity, n (%) | 1 (.5%) | -- | 1 (1%) | -- | -- | -- |
Unknown, n (%) | 3 (1%) | 6 (2%) | 2 (2%) | 4 (3%) | -- | 2 (3%) |
Other, n (%) | 19 (9%) | 19 (7%) | 11 (14%) | 17 (13%) | 1 (4%) | 8 (12%) |
Legend:
CAN = Chronic allograft nephropathy
DD = Deceased donor
LD = Living donor
CNI = Calcineurin inhibitor