TABLE 1.
Mean (± S.E.M.) potency (ED50, mg/kg) for test drugs to produce 50% ethanol-appropriate responding in male and female cynomolgus monkeys trained to discriminate 1.0 or 2.0 g/kg ethanol
The number of monkeys for whom it was possible to calculate an ED50 is shown in parentheses.
| Test Drug | 1.0 g/kg Ethanol
Training |
2.0 g/kg Ethanol
Training |
||
|---|---|---|---|---|
| Females, n = 4 | Males, n = 6 | Females, n = 4 | Males, n = 3 | |
| Ethanol a | 455 ± 48 (4) | 511 ± 79 (6) | 919 ± 24 (4) | 964 ± 18 (3) |
| Pentobarbital a | 2.66 ± 0.19 (4) | 3.12 ± 0.34 (6) | 3.88 ± 0.50 (4) | 4.70 ± 1.07 (3) |
| Midazolam | 2.10 ± 0.82 (4) | 1.25 ± 0.44 (2) | 3.11 ± 1.18 (4) | 1.49 (1) |
a
Main effect of training dose.