TABLE 3.

Results of Schild analyses of antagonism of pentobarbital substitution for the discriminative stimulus effects of 1.0 and 2.0 g/kg ethanol by Ro15-4513 or flumazenil in cynomolgus monkeys

Apparent pA₂ for individual monkeys was calculated when three or more shifts in the dose-response function (n) were obtained and the Schild slope was between −0.4 and −1.6. Apparent pK_B was calculated when less than three shifts in the dose-response function (n) were obtained.

	Females			Males
	n	Slope	pA2 a (pKB)		n	Slope	pA2 (pKB)
Ro15-4513 (1.0 g/kg ethanol training)
3123	5	−1.53	5.40	4865	3	−1.39	7.46
2830	4	−1.20	6.55	4889	4	−0.43	6.54
2852	4	−0.63	6.20	4867	4	−>0.38	NC
2913	4	−1.13	6.92	4995	1	NC	(6.68)
				4892	2	NC	(6.68)
				4864	1	NC	(6.46)
Mean		−1.12	6.27	Mean		−0.48	7.00 (6.63)
95% CI		−0.40, −1.85	5.00, 7.53	95% CI		1.26, −2.22	5.73, 8.27 (6.39, 6.87)
Ro15-4513 (2.0 g/kg ethanol training)
3220	3	−0.80	6.48	4891	3	−1.36	6.35
5400	1	NC	(5.52)	4890	2	NC	(5.88)
2835	1	NC	(7.21)	5496	0
5999	2	NC	(5.90)
Mean		−0.80	6.48 (6.13)	Mean		−1.36	6.35 (5.88)
95% CI		NC	NC (4.48, 7.79)	95% CI		NC	NC (5.59, 6.17)
Flumazenil (1.0 g/kg ethanol training)
3123	3	−0.74	4.57	4865	3	0.00004	NC
2830	2	NC	(5.00)	4892	1	NC	(5.33)
2852	2	NC	(4.79)	4867	2	NC	(4.77)
2913	1	NC	(4.76)	4864	2	NC	(4.49)
Mean		−0.74	4.57 (4.86)	Mean		0.00004	NC (4.77)
95% CI		NC	NC (4.41, 5.32)	95% CI		NC	NC (4.05, 5.49)
Flumazenil (2.0 g/kg ethanol training)
3220	2	NC	(4.77)	4891	3	−0.81	5.10
5999	2	NC	(3.63)	4890	1	NC	(4.64)
Mean		NC	(4.20)	Mean		−0.81	5.10 (4.64)
95% CI		NC	(2.66, 5.74)	95% CI		NC	NC

^a For all pA₂ analyses slopes were constrained to −1; NC, not calculable.