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Self-administration of intravenous SKF 82958 under a FR 1 schedule of reinforcement in wild-type (WT) and DATki mice. The dopamine D1 agonist SKF 82958 maintained self-administration at higher rates than saline in both wild-type mice and DATki mice. ■, 0.01 mg/kg per infusion of SKF 82958; □, saline. ∗, p < 0.05; ∗∗∗, p < 0.001 versus saline, two-sided paired-sample t test. Data are group means, bars represent one S.E.M.
