Fig. 6.
Impact of A1 receptor alkylation by FSCPX on: A, R-PIA-induced ERK1/2 phosphorylation concentration-response curves (5-min incubation) in the absence (●) or presence of 5 μM (■) or 10 μM (▴) FSCPX pretreatment (30 min) in CHO A1R cells. B, VCP-189-induced ERK1/2 phosphorylation concentration-response curves (5-min incubation) in the absence (○) or presence of 10 μM FSCPX pretreatment for 15 (□) or 30 (▵) min. Each data point is expressed as a percentage mean of ERK1/2 phosphorylation elicited by 3% FBS ± S.E.M. obtained from three to five experiments.