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Recorder tracings showing that maxadilan augments the negative chronotropic response to SP in isolated guinea pig hearts. Bolus injections of 3.2 nmol of SP were given every 20 min beginning 16 min before a single injection of 1 nmol of maxadilan. Bolus injections of 10 nmol of bethanechol were given 2 min after SP. Maxadilan had no effect on postjunctional sensitivity to the muscarinic agonist bethanechol.
