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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Mol Cancer Ther. 2009 Jul 28;8(8):2122–2130. doi: 10.1158/1535-7163.MCT-09-0115

Figure 6.

Figure 6

Effect of IGF-1R inhibition on drug sensitivity in drug resistant cells. Multidrug resistant cell line U-2OSMR was transfected with On-Targetplus SMARTpool IGF-1R siRNA as well as non-specific siRNA. A: Confirmation of IGF-1R protein knockdown by Western blot. Total protein was isolated 72 hours post-transfection and IGF-1R, pIGF-1R and Pgp1 expression was analyzed by Western blotting. B: The relative sensitivity of each treatment to doxorubicin was determined by MTT analysis 96 hours post-transfection. C: Effects of IGF-1R knockdown by siRNA on PPP sensitivity inU-2OSMR cells.

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