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Targets of biologic therapies: Mab, monoclonal antibody/biologic agent. (A) Biologic agent targeting membrane-bound molecules. Examples: anti-TNF (infliximab, adalimumab), anti-IL-6 receptor (tocilizumab), IL-1 receptor antagonist (anakinra), CTLA4 Ig (abatacept). (B) Biologic agent targeting soluble molecules. Examples: anti-TNF (infliximab, adalimumab), anti-BLyS (belimumab). TNF, tumor necrosis factor; IL, interleukin; CD, cluster of differentiation; BLyS, B lymphocyte stimulator
