TABLE IX.

Median distribution volumes (DVs) in mL/mL of (S)-5-[¹²³I]iodo-3-(2-azetidinylmethoxy)pyridine (5-[¹²³I]5IA) in the brain regions of six healthy adult volunteers with low plasma nicotine levels and six healthy adult volunteers with high plasma nicotine levels,, probability values of one-tailed exact Sign Tests of significance, Mann-Whitney U statistics, probability values of exact tests of significance of Mann-Whitney U statistics, and effect sizes of Mann-Whitney U statistics for volumes of interest (VOIs)

Brain region	Median DV of low plasma nicotine group	Median DV of high plasma nicotine group	Exact one- tailed sign test of significance P value < (SPSS, 2007)	Mann- Whitney U statistic (SPSS, 2007)	Mann- Whitney U statistic exact test of significance P value < (SPSS, 2007)	Mann- Whitney U statistic effect size estimator (Rosenthal, 1991, page 19; SPSS, 2007))
Caudate head	21.94	13.69	0.031	5.00	0.048	−0.16
Cerebellum	19.56	9.88	0.031	5.00	0.048	−0.16
Cingulate cortex	21.36	12.58	0.031	5.00	0.048	−0.16
Cortex	20.87	13.00	0.031	5.00	0.048	−0.16
Frontal cortex	17.99	9.60	0.031	4.00	0.030	−0.17
Fusiform gyrus	19.90	9.46	0.125	0.00	0.010	−0.20
Hippocampus	28.83	13.98	0.125	1.00	0.019	−0.18
Occiptal cortex	14.25	7.15	0.031	4.00	0.030	−0.17
Parahippocampus	22.18	10.83	0.125	1.00	0.019	−0.18
Parietal cortex	17.04	9.78	0.031	5.00	0.048	−0.16
Pons	29.70	17.78	0.125	2.00	0.038	−0.16
Putamen	23.84	15.63	0.031	5.00	0.048	−0.16
Temporal cortex	14.97	8.39	0.031	4.00	0.030	−0.17
Thalamus	42.25	27.50	0.031	8.00	0.149	−0.17