. Author manuscript; available in PMC: 2009 Oct 23.

Published in final edited form as: Curr Top Med Chem. 2009;9(3):241–256. doi: 10.2174/156802609788085287

Table 1.

Characteristics of Human HDACs and related X-ray structures

Class	Member	Sequence Size^a	UnitProtKB	Cellular Localization	Related PDB code^b
	HDAC1	482	Q13547	Nucleus	NA^c
I	HDAC2	488	Q92769	Nucleus	NA^d
	HDAC3	428	O15379	Nucleus	NA^d
	HDAC8	377	Q9BY41	Nucleus	1T64, 1T67, 1T69, 1VKG[19a]; 1W22[19b]; 2V5W, 2V5X[21]
IIa	HDAC4	1084	P56524	Nucleus/Cytoplasm	2VQJ, 2VQQ, 2VQM, 2VQO, 2VQV[22]
	HDCA5	1122	Q9UQL6	Nucleus/Cytoplasm	NA^c
	HDAC7	952	Q8WUI4	Nucleus/Cytoplasm	3C0Y,3C0Z,3C10 [23]
	HDAC9	1011	Q9UKV0	Nucleus/Cytoplasm	NA^c
IIb	HDAC6	1215	Q9UBN7	Cytoplasm	NA^e
	HDAC10	669	Q969S8	Cytoplasm	NA^c
IV	HDAC11	347	Q96DB2	Nucleus/Cytoplasm	NA^c
	SIRT1	747	Q96EB6	Nucleus	NA^c
	SIRT2	389	Q8IXJ6	Cytoplasm	1J8F[25]^f
	SIRT3	399	Q9NTG7	Mitochondria	NA^c
III	SIRT4	314	Q9Y6E7	Mitochondria	NA^c
	SIRT5	310	Q9NXA8	Mitochondria	2NYR, 2B4Y[26]
	SIRT6	355	Q8N6T7	Nucleus	NA^c
	SIRT7	400	Q9NRC8	Nucleus	NA^c

Sequence lengths of human HDACs are from http://www.uniprot.org/uniprot/

Catalytic domain only.

Not Available, but bacterial homologue structures 1C3P, 13CR and 1C3S [16] are available.

Not Available.

Not Available, but bacterial HDHA structures 1ZZ0, 1ZZ1, 1ZZ3 and 2GH6 [24] are available.

Sirt2 structures for other species. 1YC5[28], 1S7G[29], 1M2G[30], 1S5P[31], 1MA3[69], 1ICI [70].