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. 2009 Oct 13;2:14. doi: 10.3389/neuro.16.014.2009

Figure 1.

Figure 1

Comparison of principal designs for voltage-sensitive fluorescent proteins. (A) FRET-based voltage probe. Cyan- and yellow-emitting GFP variants are connected by a short linker. (B) Single FP-based voltage probe. (C) Circularly permuted FP-based voltage probe. The N- and C-terminal portions of GFP are swapped, resulting in new N- and C-terminal ends. The color gradient (from purple to red) shows the progression from the N- to the C-terminus of the original protein. Note the direct attachment of the GFP reporter to the S4 domain.