Table 1.
Core presynaptic list containing 117 proteins.
| Accession # (UniProt) | Protein Name | Gene Name (Entrez Gene) |
|---|---|---|
| Trafficking (32) | ||
| Q10567 | AP-1 complex subunit beta-1 | AP1B1 |
| O95782 | AP-2 complex subunit alpha-1 | AP2A1 |
| O94973 | AP-2 complex subunit alpha-2 | AP2A2 |
| P63010 | AP-2 complex subunit beta-1 | AP2B1 |
| Q96CW1 | AP-2 complex subunit mu-1 | AP2M1 |
| Q93050 | V-ATPase subunit a1 | ATP6V0A1 |
| P61421 | V-ATPase subunit d | ATP6V0D1 |
| P38606 | V-ATPase subunit A1 | ATP6V1A |
| P21281 | V-ATPase subunit B2 | ATP6V1B2 |
| P21283 | V-ATPase subunit C | ATP6V1C1 |
| P36543 | V-ATPase subunit E | ATP6V1E1 |
| P09496 | Clathrin light chain | CLTA |
| Q00610 | Clathrin heavy chain | CLTC |
| Q05193 | Dynamin 1 | DNM1 |
| Q14204 | Dynein heavy chain, cytosolic | DYNC1H1 |
| P54920 | Alpha-soluble NSF attachment protein | NAPA |
| P46459 | N-ethylmaleimide sensitive fusion protein | NSF |
| Q9BY11 | Protein kinase C and casein kinase substrate in neurons protein 1 | PACSIN1 |
| P20336 | Ras-related protein Rab-3A | RAB3A |
| Q86UR5 | Rab3-interacting molecule 1 | RIMS1 |
| Q99962 | SH3-containing GRB2-like protein 2 | SH3GL2 |
| Q9Y6R1 | Synaptosomal-associated protein 25 | SNAP25 |
| Q16623 | Syntaxin 1A | STX1A |
| P61764 | Syntaxin-binding protein 1 | STXBP1 |
| Q15833 | Syntaxin-binding protein 2 | STXBP2 |
| P17600 | Synapsin 1 | SYN1 |
| Q92777 | Synapsin 2 | SYN2 |
| O43426 | Synaptojanin 1 | SYNJ1 |
| P21579 | Synaptotagmin 1 | SYT1 |
| Q8N9I0 | Synaptotagmin 2 | SYT2 |
| Q96QK1 | Vacuolar protein sorting 35 | VPS35 |
| P63027 | Vesicle-associated membrane protein 2 | VAMP2 |
| Signaling (22) | ||
| Q2M2I8 | AP-2 associated kinase 1 | AAK1 |
| P62158 | Calmodulin | CALM1 |
| Q9UQM7 | CAMKII alpha | CAMK2A |
| P09543 | 2′,3′-cyclic-nucleotide 3′-phosphodiesterase | CNP |
| P68400 | Casein kinase II subunit alpha | CSNK2A1 |
| Q16555 | Dihydropyrimidinase-related protein 2 | DPYSL2 |
| P63096 | G protein G(i) alpha 1 | GNAI1 |
| P04899 | G protein G(i) alpha 2 | GNAI2 |
| P08754 | G protein G(i) alpha 3 | GNAI3 |
| P09471 | G protein G(o) alpha 1 | GNAO1 |
| P62873 | G protein beta 1 | GNB1 |
| P62879 | G protein beta 2 | GNB2 |
| P07948 | Tyrosine-protein kinase Lyn | LYN |
| P28482 | Mitogen-activated protein kinase 1 | MAPK1 |
| Q9NQ66 | Phospholipase C beta 1 | PLCB1 |
| Q08209 | Protein phosphatase 2B catalytic subunit alpha isoform | PPP3CA |
| P16298 | Protein phosphatase 2B catalytic subunit beta isoform | PPP3CB |
| P17252 | Protein kinase C alpha type | PRKCA |
| P31946 | 14-3-3 protein beta/alpha | YWHAB |
| P62258 | 14-3-3 protein epsilon | YWHAE |
| Q04917 | 14-3-3 protein eta | YWHAH |
| P63104 | 14-3-3 protein zeta/delta | YWHAZ |
| Receptors/Channels (3) | ||
| P13637 | Na/K ATPase alpha-3 chain | ATP1A3 |
| P21796 | Voltage-dependent anion-selective channel protein 1 | VDAC1 |
| P45880 | Voltage-dependent anion-selective channel protein 2 | VDAC2 |
| Scaffolding/Clustering (2) | ||
| Q01484 | Ankyrin 2 | ANK2 |
| Q9UQF2 | JNK-interacting protein 1 | MAPK8IP1 |
| Cell Adhesion (4) | ||
| Q12860 | Contactin 1 | CNTN1 |
| P32004 | Neural cell adhesion molecule L1 precursor | L1CAM |
| P13591 | Neural cell adhesion molecule 1 | NCAM1 |
| Q92823 | Neuronal cell adhesion molecule precursor | NRCAM |
| Cytoskeletal (23) | ||
| P68133 | Alpha-actin 1 | ACTA1 |
| P60709 | Beta-actin | ACTB |
| P63261 | Gamma-actin | ACTG1 |
| P12814 | Alpha-actinin 1 | ACTN1 |
| P35609 | Alpha-actinin 2 | ACTN2 |
| Q08043 | Alpha-actinin 3 | ACTN3 |
| P35611 | Adducin 1 | ADD1 |
| Q13561 | Dynactin subunit 2 | DCTN2 |
| P11171 | Protein 4.1 | EPB41 |
| P11137 | Microtubule-associated protein 2 | MAP2 |
| P07196 | Neurofilament triplet L protein | NEFL |
| Q9UH03 | Septin 3 | SEPT3 |
| Q99719 | Septin 5 | SEPT5 |
| Q16181 | Septin 7 | SEPT7 |
| Q13813 | Spectrin alpha chain, brain | SPTAN1 |
| Q01082 | Spectrin beta chain, brain 1 | SPTBN1 |
| O15020 | Spectrin beta chain, brain 2 | SPTBN2 |
| P09493 | Tropomyosin 1 alpha chain | TPM1 |
| P68366 | Tubulin alpha 1 chain | TUBA1 |
| Q9BQE3 | Tubulin alpha 6 chain | TUBA6 |
| P07437 | Tubulin beta 2 chain | TUBB2A |
| Q13509 | Tubulin beat 3 chain | TUBB3 |
| P04350 | Tubulin beta 4 chain | TUBB4 |
| Regulatory (7) | ||
| P13639 | Elongation factor 2 | EEF2 |
| P63241 | Eukaryotic translation initiation factor 5A-1 | EIF5A |
| P07900 | Heat shock protein 90 alpha | HSP90AA1 |
| P11142 | Heat shock cognate 71 kDa protein | HSPA8 |
| P49411 | Elongation factor Tu, mitochondrial | TUFM |
| P62937 | Peptidyl-prolyl cis-trans isomerase A | PPIA |
| P35232 | Prohibitin | PHB |
| Metabolic/Mitochondrial (16) | ||
| P04075 | Aldolase A | ALDOA |
| P25705 | ATP synthase subunit alpha | ATP5A1 |
| P06576 | ATP synthase subunit beta | ATP5B |
| P12277 | Creatine kinase B chain | CKB |
| P12532 | Creatine kinase ubiquitous | CKMT1A |
| P08574 | Cytochrome c-1 | CYC1 |
| P10515 | Pyruvate dehydrogenase complext E2 subunit | DLAT |
| P00367 | Glutamate dehydrogenase 1 | GLUD1 |
| P19367 | Hexokinase 1 | HK1 |
| P50213 | Isocitrate dehydrogenase [NAD] subunit alpha | IDH3A |
| O95299 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10 | NDUFA10 |
| O75489 | NADH-ubiquinone oxidoreductase 30 kDa subunit | NDUFS3 |
| P17858 | 6-phosphofructokinase, liver type | PFKL |
| P08237 | 6-phosphofructokinase, muscle type | PFKM |
| P14618 | Pyruvate kinase isozymes M1/M2 | PKM2 |
| P22695 | Ubiquinol-cytochrome-c reductase complex core protein 2 | UQCRC2 |
| Other (8) | ||
| P69905 | Hemoglobin subunit alpha | HBA1 |
| P68871 | Hemoglobin subunit beta | HBB |
| P02686 | Myelin basic protein | MBP |
| O60313 | Dynamin-like 120 kDa protein | OPA1 |
| Q99584 | Protein S100-A13 | S100A13 |
| P04216 | Thy-1 membrane glycoprotein precursor | THY1 |
| P55072 | Valosin-containing protein | VCP |
| P62760 | Visinin-like protein 1 | VSNL1 |