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. 2009 Aug 13;18(22):4329–4339. doi: 10.1093/hmg/ddp385

Figure 7.

Figure 7.

OS morphogenesis and degeneration were observed by scanning electron microscopy of control and Rpgrip1nmf247 mutant retina at P7 (A, B), P12 (C, D), 3 weeks (F, H) and 4 weeks (E, G, H). Specimens were viewed from an RPE orientation (A–G) or fractured and viewed from a neuroretinal orientation (H). In control retinas, at P7, developing OS were observed (OS, A) and at P12, elongation of OS was observed (C). In contrast, in Rpgrip1nmf247 mutant retinas no OS were observed at P7 (B) and rare rudimentary OS budding was observed at P12 (OS, D). Asterisks indicate RPE adherence to the IS (F) in Rpgrip1nmf247 mutants. The photoreceptor nuclei (N) are noted (G, H). The degeneration is rapid and progressive with CC no longer observable on IS at 3 weeks (F and arrows, H) and with very rare IS at 4 weeks (G and arrow, H). OS, outer segment; IS, inner segment; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GC, ganglion cells; RPE, retinal pigment epithelium; CC, connecting cilium; NC, nascent cilia. Bars = 10 µm.