Figure 2.—

Dominant Mad–sax interactions. (A) Mad–sax MEL. The percentage of lethality of progeny from females heterozygous for various Mad and sax alleles crossed to wild-type males is depicted by bars. Transheterozygous (Mad +/+ sax) females show significant maternal effect lethality. Female genotypes are listed on the x-axis. n ≥ 300 embryos scored for control crosses and n ≥ 475 embryos for experimental crosses. (B) Mad–sax zygotic enhancement of the dpp^d12 disk mutation. The number of legs per individual with tarsal claws was quantified in progeny from dpp^d12/+ females crossed to males bearing a Mad⁻ sax⁻ double mutant chromosome (Df(2L)JS17 sax¹/CyO23) (dark bars) or only Mad⁻ (light bars). A lowering of both Mad and sax dosage results in an enhancement of tarsal claw loss associated with a reduction in dpp function.