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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: J Neurochem. 2009 Sep 18;111(4):1062–1073. doi: 10.1111/j.1471-4159.2009.06388.x

Figure 8. Proposed model of how p62 may target mutant SOD1 aggregates to autophagy.

Figure 8

LC3-II represents the phosphatidylethanolamine-conjugated form of LC3 and is associated with the autophagosomal membrane. Misfolded mutant SOD1 is recognized by p62, sequestered to form inclusions, and targeted to autophagy.