Table 5.

Impact of HMDS diagnosis on patient management

Group (N)	Initial diagnosis	Effect of final HMDS diagnosis on patient management	Examples
1 (48)	Correct diagnosis	Initial diagnosis confirmed; no alteration in management	Hodgkin disease
			Rosai Dorfman
2 (23)	No firm diagnosis made; correct final diagnosis included in differential diagnosis	HMDS diagnosis altered management	NR
3 (16)	Final diagnosis not included in initial differential diagnosis	Final diagnosis did not affect management	NK cell leukaemia
4 (23)	Final diagnosis not included in initial differential diagnosis	Final diagnosis altered management	Nasopharyngeal carcinoma Tuberculosis
5 (40)	Patient died, lost to follow-up or inadequate/unobtainable sample	Final diagnosis did not affect management	NR

NR not relevant