Table 5.
P9 | P22 | |
---|---|---|
Sham | 0.0472±0.007 (n=11) | 0.170±0.021 (n=5) |
Control | 0.009±0.004* (n=11) | 0.080±0.050* (n=5) |
IGF-PT0h | 0.033±0.014*# (n=11) | 0.124±0.015*# (n=6) |
IGF-PT1h | 0.028±0.010*# (n=11) | 0.130±0.023*# (n=6) |
Mean optical density of MBP staining was determined as described in Methods. Cerebral HI decreased the MBP staining in both the P9 and P22 rat brain, while IGF-1 treatment at 0 or 1 h after HI partially reversed the HI-induced hypomyelination.
P<0.05 as compared to the sham group.
P<0.05 as compared to the HI control group.