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. Author manuscript; available in PMC: 2009 Nov 24.
Published in final edited form as: Neuroscience. 2009 May 18;164(1):88–107. doi: 10.1016/j.neuroscience.2009.05.013

Table 2.

Parameters for memory and intelligence effect (sizes)

# 1st Author PMID Source Gene SNP Task Indicator (condition) Statistic Stat
value		 P-value N Cohen’s d
Memory effects
1 Gondo 16095668 Task 5-HTT S/L allele MMSE Cognitive function Not reported 265
2 Reynolds 17564514 Concept 5-HTT U79746 [exon 1B −925 T/G] Thurston Picture Memory Quadratic change score at age 65 F(,) 3.13 0.05 112 0.31
3 Roiser 16893493 Concept 5-HTT S/L allele/tryptophan depletion CANTAB pattern recognition Percent correct P-value only 0.05 30 0.62
4 Strange 18614671 Concept 5-HTT S/L allele Word Perception Task # Items recalled F(1,26) 4.865 0.036 28 0.71
5 Mannie 18775088 Direct 5-HTT S/L allele RAVLT Delayed recall No stats, ES derived from means/SD 31
5-HT avg		 0.32
0.41
6 Albert 17402816 Concept APOE Presence of e4 composite Episodic memory Mixed model 0.89 0.001 327 0.34
7 Andersson 17124416 Concept APOE Presence of e4 RAVLT Delayed recall score used for group assignment Not reported 124
8 Andersson 17124416 Concept APOE Presence of e4 MMSE Cognitive status P-value only 0.01 124 0.42
9 Deary 15222832 Task APOE Presence of e4 WMS-R logical memory Delayed recall F(1,457) 7.84 0.005 462 0.24
10 Ferguson 12502505 Task APOE Presence of e4 Borkowski verbal fluency # Of items in 60 s P-value only 0.063 96 0.31
11 Fiocco 18374494 Concept APOE Presence of e4 Unrelated word pairs (not normed) Total recall of word pairs Not reported 63
12 de Frias 17379671 Concept APOE Presence of e4 Episodic memory (from factor structure −nyberg03) Recall composite score t () 5.69 0.001 524 0.27
13 de Frias 17379671 Concept APOE Presence of e4 episodic memory (from factor structure −nyberg03) Recognition composite score t () 6.2 0.001 524 0.27
14 de Frias 17379671 Concept APOE Presence of e4 Episodic memory (from factor structure −nyberg03) Fluency composite score t () 4.65 0.001 524 0.27
15 Halkala 7644133 Task APOE Presence of e4 Buschke’s list learning Total recalled over six trials P-value only 0.01 916 0.15
16 Halkala 7644133 Task APOE Presence of e4 Visual Reproduction Test Reproduce three figures Not reported 916
17 Harwood 12075916 Task APOE Presence of e4 MMSE Age and education adjusted score OR 9.5 0.004 57 0.74
18 Helkala 8938259 Concept APOE Presence of e4 Buschke’s list learning; figure recall Sum of word list recall over six trials P-value only 0.003 632 0.22
19 Jorm 17201525 Concept APOE Presence of e4 CVLT Delayed recall P-value only 0.91 6560 0.03
20 Mondadori 17077159 Concept APOE Presence of e4 Associative encoding Delayed recall Odds ratio 1.6 0.009 340 0.26
21 Nilsson 17100509 Concept APOE Presence of e4 Composite Composite score for recall data F(4,1542) 6.48 0.005 657 0.20
22 Reynolds 17564514 Concept APOE Presence of e4 Thurston Picture Memory Quadratic change score at age 65 F(,) 1.22 150
23 Schultz 18235080 Concept APOE Presence of e4 WMS-III Logical memory subtest, immediate and delayed recall F(1,617) 6.79 0.009 626 0.19
24 Strandburg 15748778 Task APOE Presence of e4 MMSE Cognitive impairment P-value only 0.02 357 0.22
25 Tagarakis 17606532 Task APOE Presence of e4 MMSE Cognitive impairment Not reported 137
26 Tagarakis 17606532 Task APOE Presence of e4 WMS-R Cognitive impairment Not reported 137
27 van Munster 17728664 Task APOE Presence of e4 MMSE Cognitive impairment P-value only 0.057 72 0.37
28 Yip 12205106 Task APOE Presence of e4 MMSE Dementia Adjusted OR 1.5 2034
APOE avg
0.12
29 Egan 12553913 Concept BDNF val66met WMS-R Recall of items from two stories after 30 min delay F(2,591) 3.89 0.02 641 0.16
30 Dempster 15719396 Direct BDNF val66met WMS-R logical memory Delayed recall t() −2.65 0.01 114 0.44
31 Hariri 12890761 Concept BDNF val66met Scene Recognition Task Old/new judgment— percent correct F(1,26) 9.44 0.005 64 0.67
32 Harris 16446742 Task BDNF val66met Verbal fluency # Words in 1 min F(,) 1.3 0.28 460 0.05
33 Harris 16446742 Task BDNF val66met Logical memory Recall of items in story F(,) 1.7 0.19 460 0.08
34 Harris 16446742 Task BDNF val66met Moray House Test (MHT) Test of verbal reasoning taken at age 11 F(,) 4.2 0.016 460 0.20
35 Strauss 15626819 Concept BDNF val66met Verbal declarative memory Composite score F(4,54) 1.4 0.25 19
BDNF avg		 0.31
0.23
36 Apud 17063156 Concept COMT val158met Free recall of word list # Correct/15 words Not reported 47
37 Frias 15319576 Concept COMT val158met Recall test; recognition tests # Correct/16 items over three tests F(2,277) 3.29 0.04 286 0.21
38 Harris 15979789 Concept COMT val158met WMS-R logical memory portion Recall of items in story F(,) 3.6 0.028 460 0.18
39 Strauss 15626819 Concept COMT val108/158met WMS Logical memory (delayed) subtest F(4,54) 0.49 0.15 49 0.30
40 Strauss 15626819 Concept COMT val158met Paired assoc learning Delayed score F(4,54) 0.49 0.79 49
COMT avg		 0.23
0.17
41 Nacimas 18378080 Concept KIBRA T/C allele (rs 17070145) 24-h Delayed Five Words Recall Recall of five and paired words 24 h delay P-value only 0.04 70 0.42
42 Nacimas 18378080 Concept KIBRA T/C allele (rs 17070145) Short Story Immediate recall P-value only 0.03 70 0.45
43 Need 18205171 Task KIBRA T/C allele (rs 17070145) CANTAB verbal recall Not provided P-value only 0.63 319 0.04
44 Need 18205171 Task KIBRA T/C allele (rs 17070145) Story recall (Green, 2005) Not provided P-value only 0.39 319 0.03
45 Need 18205171 Task KIBRA T/C allele (rs 17070145) AVLT Delayed recall P-value only 0.56 365 0.02
46 Schaper 17353070 Concept KIBRA T/C allele (rs 17070145) Verbal Learning and Memory Test Total recall Effect size d 0.74 0.004 64 0.74
47 Almeida 18194457 Direct KIBRA T/C allele (rs 17070145) CERAD Delayed recall F(,) 3.91 0.049 312
KIBRA avg		 0.19
0.19
48 Luciano 19077176 DTNBP1 rs 742105 English cohort Verbal declarative memory Memory cumulative recall t −2.67 0.01 745 0.168
49 Luciano 19077176 DTNBP1 rs 742105 English cohort Verbal declarative memory Delayed recall t −1.93 0.05 745 0.119
50 Luciano 19077176 DTNBP1 rs 742105 English cohort Verbal declarative memory Memory factor t −2.32 0.02 745 0.149
51 Luciano 19077176 DTNBP1 6-SNP Burdick risk haplotype ACT in Scottish cohort Verbal declarative memory Logical memory immediate F(1,1022) 4.55 0.03 1054
DTNBP1 avg		 0.114
0.14
Intelligence effects
1 Turic 11166947 Con APOE apoE/−491 AT WISC High g (136)>avg g (103) Chi 2.599 0.761 202 0.10
2 Turic 11166947 Con APOE apoE/Th1/e47cs WISC High g (136)>avg g (103) Chi 3.364 0.498 202 0.00
3 Turic 11166947 Con APOE Presence of e4 WISC High g (136)>avg g (103) Chi 2.877 0.238 202 0.23
4 Pendleton 11983298 Con APOE Presence of e4 Heim Ah4 part 1 score t () −0.7 0.48 767 0.05
5 Ferguson 12502505 Task APOE Presence of e4 WAIS PIQ raw score P-value only 0.037 96 0.33
6 Puttonen 12886039 Con APOE Presence of e4 Mental Arithmetic Correct trials t () 57 −0.42
7 Puttonen 12886039 Con APOE Presence of e4 Mental Arithmetic Adjusted correct trials t () 57 −0.51
8 Puttonen 12886039 Con APOE Presence of e4 Mental Arithmetic # Of trials t () 57 −0.46
9 Deary 15222832 Task APOE Presence of e4 Ravens Correct completed F(1,457) 1.46 0.23 1462
APOE avg		 0.11
0.09
10 Harris 16446742 Con BDNF val66met Ravens Correct completed F(,) 7 0.001 904 0.20
11 Harris 16446742 Con BDNF val66met Moray House Test F(,) 4.2 0.016 904 0.14
12 Tsai04 From savitz BDNF WAIS Piq P-value only 0.046 114 0.30
13 Goldberg 17988784 Task BDNF matched IQ Not applicable
BDNF avg
0.21
14 Comings 12556901 Con CHRM2 a->t 1890 WAIS-R Fsiq F(,) 4.12 0.017 828 0.15
15 Dick 17160701 Task CHRM2 8 SNPS <0.05 WAIS-R Piq 8 SNPs P<05 0.05 1113 0.10
16 Gosso 17996044 Con CHRM2 rs 2061174 WAIS-R Piq Chi 9.14 0.003 391 0.28
17 Gosso 17996044 Con CHRM2 rs 323650 WISC Viq Chi 9.5 0.002 371
CHRM2 avg		 0.30
0.17
18 Barnett 17202556 Direct COMT Val158Met WISC Viq F(2,1763) 9.97 0.001 8707 0.21
19 Barnett 17202556 Direct COMT Val158Met WISC Fsiq F(2,1639) 4.28 0.05 8707 0.15
20 Malhotra 11925305 Task COMT Val158Met WCST Perseverative errors F(2,70) 4.43 0.02 73 0.71
21 Reuter 16026865 Con COMT Val158Met Not reported 96
22 de Frias 16102234 Con COMT Val158Met WAIS Block design F(1,285) 4.59 0.03 292 0.25
23 Starr 17548151 Task COMT Val158Met Ravens Correct completed F(2935.7) 7.92 0.001 473 0.26
24 Tsai03 12566168 Savitz COMT Val158Met WCST Perseverative errors P-value only 0.755 120 0.12
25 Tsai03 12566168 Savitz COMT Val158Met WAIS Viq P-value only 0.431 120 0.03
26 Tsai03 12566168 Savitz COMT Val158Met WAIS Piq P-value only 0.658 120 0.07
27 Tsai03 12566168 Savitz COMT Val158Met WAIS Fsiq P-value only 0.511 120
COMT avg		 0.00
0.21
28 Ball 9507981 Task DRD2 TaqI A1/A2 WISC High g (136)>avg g (105) 0.41 102 0.04
29 Rodriguez–Jimenez 17230034 Task DRD2 C957T WCST Perseverative errors F 5.849 0.018 83 0.73
30 Han 18555060 Task DRD2 TaqI A1/A2 WCST Not reported 40
31 Tsai02 11979061 Task DRD2 TaqI A1/A2 WISC Piq 0.036 112 0.34
32 Tsai02 11979061 Task DRD2 TaqI A1/A2 WISC Viq 0.289 112 0.10
33 Petrill 9145541 Savitz DRD2 TaqI A1/A2 WISC High g (51)>avg g (51)>low g (35) Not significant, not reported 137
34 Berman 7755518 Savitz DRD2 TaqI A1/A2 WISC Fsiq No stats, ES derived from means/sd 73
DRD2 avg		 0.07
0.29
35 Burdick 16415041 DTNBP1 CTCTAC risk haplotype General cognitive ability Composite factor score F(1,125) 4.29 0.04 126 0.311
36 Luciano 19077176 DTNBP1 rs 1047631 English cohort Cattell Culture fair t −2.12 0.03 745 0.136
37 Luciano 19077176 DTNBP1 3-SNP Donohoe risk haplotype ACT in English cohort General ability Alice heim 2 F(1,728) 3.73 0.05 745 0.119
38 Luciano 19077176 DTNBP1 3-SNP Donohoe risk haplotype ACT in English cohort General ability G factor (Wave 1) F(1,688) 5.67 0.02 745 0.149
39 Luciano 19077176 DTNBP1 rs 742105 English cohort General ability G factor (Wave 2) t −2.19 0.03 745 0.136
40 Luciano 19077176 DTNBP1 6-SNP Burdick risk haplotype ACT in Australian cohort Verbal ability Nart 0.04 1806 0.081
41 Luciano 19077176 DTNBP1 3-SNP Donohoe risk haplotype ACT in English cohort Verbal ability Mill hill a F(1,724) 11.82 0.001 745 0.224
42 Luciano 19077176 DTNBP1 rs 2619539 English cohort Verbal ability Mill hill a t 2.09 0.04 745
DTNBP1 avg		 0.127
0.13

Cohen’s d effect sizes were calculated from t or F statistics when degrees of freedom were provided. Otherwise, P-value and sample size were used to calculate (Cohen’s d) effect sizes. This table contains incomplete information, only what we were able to glean from the article. All effects are available online (http://phenowiki.org), and we encourage the authors to fill in missing data for their studies. To compute averages we only chose one effect per (independent) sample. We chose the strongest evidence for implication of that gene for the average, but this table contains additional relevant effects. “From” column, notes what method was used to find that paper (either from our task, concept, or direct search strategy, or cross-pollination from a paper already in the list).