Table 2.
Distribution of NAT2 acetylator genotypes among gastric cancer cases and controls
| NAT2 genotype | Cases (n = 471) | Controls (n = 471) | OR (95% CI) | ||
|---|---|---|---|---|---|
| No. | %a | No. | %a | ||
| Rapid acetylators | |||||
| NAT2*4 /*4 | 211 | 44.8 | 193 | 41.0 | |
| NAT2*4 /*12A | 0 | 0 | 1 | 0.2 | |
| NAT2*4 /*13 | 0 | 0 | 4 | 0.9 | |
| Total rapid acetylators | 211 | 44.8 | 198 | 42.0 | 1.0 (Reference) |
| Intermediate acetylators | |||||
| NAT2*4 /*5B | 12 | 2.6 | 13 | 2.8 | |
| NAT2*4 /*6A | 120 | 25.5 | 126 | 26.8 | |
| NAT2*4 /*6C | 1 | 0.2 | 1 | 0.2 | |
| NAT2*4 /*7B | 70 | 14.9 | 74 | 15.7 | |
| NAT2*4 /*10 | 0 | 0 | 1 | 0.2 | |
| NAT2*6A /*13 | 1 | 0.2 | 0 | 0 | |
| Total intermediate acetylators | 204 | 43.3 | 215 | 45.7 | 0.89 (0.68-1.17)b |
| Slow acetylators | |||||
| NAT2*5B /*6A | 4 | 0.9 | 3 | 0.6 | |
| NAT2*5B /*7B | 2 | 0.4 | 2 | 0.4 | |
| NAT2*6A /*6A | 16 | 3.4 | 22 | 4.7 | |
| NAT2*7B /*7B | 9 | 1.9 | 5 | 1.1 | |
| NAT2*6 A /*7B | 25 | 5.3 | 26 | 5.5 | |
| Total slow acetylators | 56 | 11.9 | 58 | 12.3 | 0.95 (0.77-1.17)b |
| NAT2 acetylators activity | |||||
| Rapid | 211 | 44.8 | 198 | 42.0 | 1.0 (reference) |
| Slow / intermediate | 260 | 55.2 | 273 | 58.0 | 0.94 (0.83-1.08)c |
a
(participants with genotype/total cases or controls)*100.
b
Unconditional logistic regression adjusted for gender and age.
c
Conditional logistic regression stratified by age and gender.