Table 3.
Unadjusted and adjusted hazard ratios (HR) and 95% confidence intervals (CI) of the ID and DD genotypes relative to the II genotype for combined randomized groups.
| II | ID | DD | |||
|---|---|---|---|---|---|
| reference | HR (unadjusted) 95% CI | HR (adjusted)1 95% CI | HR (unadjusted) 95% CI | HR (adjusted) 1 95% CI | |
| All Cause Mortality | 1 | 1.12 (0.96, 1.31) | 1.11 (0.94, 1.29) | 1.09 (0.91, 1.29) | 1.08 (0.91, 1.29) |
| CVD mortality | 1 | 1.13 (0.90, 1.42) | 1.12 (0.89, 1.41) | 1.04 (0.81, 1.33) | 1.03 (0.80, 1.33) |
| CHD | 1 | 1.25 (0.91, 1.71) | 1.25 (0.91, 1.71) | 1.11 (0.79, 1.57) | 1.10 (0.78, 1.56) |
| Stroke | 1 | 0.59 (0.35, 1.00) | 0.59 † (0.35, 0.99) | 1.00 (0.60, 1.67) | 0.96 (0.57, 1.61) |
| Other CVD | 1 | 1.40 (0.90, 2.19) | 1.36 (0.87, 2.13) | 0.93 (0.56, 1.56) | 0.95 (0.57, 1.58) |
| Non-CVD mortality | 1 | 1.13 (0.89, 1.42) | 1.11 (0.88, 1.40) | 1.13 (0.88, 1.45) | 1.14 (0.88, 1.46) |
| Fatal CHD and nonfatal MI | 1 | 1.13 (0.92, 1.38) | 1.14 (0.93, 1.39) | 1.19 (0.96, 1.48) | 1.20 (0.97, 1.49) |
| Stroke (fatal and nonfatal) | 1 | 0.78 (0.61, 1.01) | 0.76 ‡ (0.59, 0.98) | 1.04 (0.80, 1.36) | 1.00 (0.76, 1.31) |
| Heart Failure (hospitalized or fatal) | 1 | 1.04 (0.81, 1.32) | 1.03 (0.81, 1.31) | 0.98 (0.75, 1.27) | 0.98 (0.75, 1.28) |
1
Adjusted for treatment group (pravastatin/usual care), sex (male/female), race (black/white), and eight baseline variables: current smoking status (yes/no), history of diabetes (yes/no), history of CHD (yes/no), systolic blood pressure level (mm Hg), and age (years).
†
p = 0.047
‡
p = 0.038