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. Author manuscript; available in PMC: 2010 Oct 8.
Published in final edited form as: J Med Chem. 2009 Oct 8;52(19):6107–6125. doi: 10.1021/jm901096y

Figure 2.

Figure 2

Example structures and activities of holdout ligands (left) and blind testing ligands from the Organon set (right). The body types A–D indicated for the former describe, respectively, the angular cis, linear trans, angular trans, and linear cis ring configurations. Type E describes a variant of type A in which the nitrogen-containing ring has four members, and type F describes a cyclic urea scaffold. The Organon set contained diverse scaffolds, which included the prototypical amino-tetralin 8-OH-DPAT, multiple aryl-piperazines, as well as drugs such as pindolol and sumatriptan. Compound numbers are as in ref 16.