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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Immunol Rev. 2008 Dec;226:112–131. doi: 10.1111/j.1600-065X.2008.00700.x

Fig. 4. Role of dectin-1, TLR2, and TLR8 in IL-12 and IL-23 production in DC.

Fig. 4

DC treated with IFN-γ (red columns) or left untreated (blue columns) were stimulated with β-glucan or Pam2C (TLR2-ligand), or with a combination of β-glucan plus Pam2C, with or without R848 (TLR7/8-ligand). Cell extracts after 12 h culture were tested for mRNA accumulation using the QuantiGene multiplex assay (left panels). Supernatants after 18 h culture were tested for IL-23 and IL-12 protein production by ELISA (Right panels). Modified from Ref. (63).