Table 4. Risk of MI Associated with CETP Haplotypes.
| CETP SNP | Men | Women | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Haplotype | -2708 | -971 | -629 | TaqI | Ex 14 | Haplotype Frequencies | ORa (95% CI) | Haplotype Frequencies | ORa (95% CI) | ||
| Alleles | Case | Control | Case | Control | |||||||
| Hap A | G | G | A | A | G | 0.086 | 0.080 | 1.36 (0.83-2.20) | 0.082 | 0.073 | 0.94 (0.59-1.49) |
| 1.32 (0.76-2.27) | 0.82 (0.49-1.39) | ||||||||||
| Hap B | G | G | A | A | A | 0.009 | 0.029 | 0.37 (0.11-1.21)* | 0.030 | 0.024 | 1.17 (0.47-2.91) |
| 0.18 (0.04-0.75)** | 1.02 (0.33-3.08) | ||||||||||
| Hap C | G | G | C | G | G | 0.091 | 0.082 | 1.15 (0.66-1.99) | 0.089 | 0.063 | 1.03 (0.61-1.74) |
| 1.23 (0.65-2.33) | 1.14 (0.62-2.12) | ||||||||||
| Hap D | G | G | C | G | A | 0.268 | 0.293 | Reference group | 0.302 | 0.257 | Reference group |
| Hap E | G | A | A | A | G | 0.016 | 0.032 | 0.76 (0.39-1.49) | 0.020 | 0.032 | 0.67 (0.34-1.29) |
| 0.91 (0.43-1.93) | 0.86 (0.40-1.84) | ||||||||||
| Hap F | G | A | A | A | A | 0.049 | 0.028 | 1.56 (0.79-3.04) | 0.035 | 0.050 | 0.60 (0.31-1.16) |
| 1.35 (0.61-2.97) | 0.59 (0.27-1.29) | ||||||||||
| Hap G | G | A | A | G | G | 0.046 | 0.018 | 4.05 (1.84-8.91)** | 0.032 | 0.026 | 0.79 (0.31-1.58) |
| 5.98 (2.40-14.78)** | 0.96 (0.43-2.17) | ||||||||||
| Hap H | G | A | A | G | A | 0.026 | 0.020 | 1.32 (0.55-3.15) | 0.014 | 0.0276 | 0.54 (0.22-1.34) |
| 1.02 (0.39-2.62) | 0.46 (0.16-1.35) | ||||||||||
| Hap J | G | A | C | G | A | 0.101 | 0.086 | 1.47 (0.94-2.30) | 0.098 | 0.107 | 0.79 (0.51-1.22) |
| 1.48 (0.89-2.47) | 0.85 (0.51-1.42) | ||||||||||
| Hap K | A | A | A | A | G | 0.070 | 0.093 | 0.89 (0.56-1.43) | 0.095 | 0.131 | 0.65 (0.43-1.00) |
| 0.94 (0.55-1.61) | 0.82 (0.50-1.34) | ||||||||||
| Hap L | A | A | A | A | A | 0.181 | 0.169 | 1.16 (0.80-1.67) | 0.158 | 0.181 | 0.67 (0.45-0.99) |
| 1.31 (0.87-1.97) | 0.81 (0.51-1.28) | ||||||||||
|
| |||||||||||
| Global Scoreb& P value | 19.07 (0.0599) | 13.98 (0.234) | |||||||||
| 24.86 (0.0009) | 9.83 (0.545) | ||||||||||
a
Odds ratios (OR) and 95% confidence interval (95% CI) are for each additional copy of the haplotype allele, relative to subjects homozygous for the reference haplotype group. Upper estimates are adjusted for age and race and lower estimates are adjusted for age and race, education, smoking, BMI and HDL-C.
b
Score and p-value in parenthesis from a global association test between CETP haplotypes and MI risk
*
p≤ 0.05 from haplotype specific score test
**
p ≤ 0.01 from haplotype specific score test