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. Author manuscript; available in PMC: 2010 Jul 9.
Published in final edited form as: J Med Chem. 2009 Jul 9;52(13):4038–4053. doi: 10.1021/jm900356n

Figure 2.

Figure 2

In vivo potency of new 5-NI compounds against giardiasis. Adult C57BL/6 mice were infected orally with G. lamblia GS/M and given the indicated compounds at 10 or 2 mg/kg or vehicle only by oral gavage five times over a 3-day period starting 2 days after infection. Trophozoite numbers in the small intestine were determined 5 days after infection. Data are mean ± SE of 3–7 animals. Asterisks designate a significant decrease (p < 0.05, t test) relative to infection controls given vehicle only. The gray line depicts the sensitivity of the assay. The in vitro activies of the respective compounds are taken from Tables 2–4.