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. Author manuscript; available in PMC: 2010 Jul 9.
Published in final edited form as: J Med Chem. 2009 Jul 9;52(13):4038–4053. doi: 10.1021/jm900356n

Figure 3.

Figure 3

Resistance profiles of new 5-NI derivatives. EC50 of all new compounds were determined for MzR and MzS lines of G. lamblia 713 and 106. The ability to overcome Mz resistance is expressed as the ratio of EC50 in the MzR line over EC50 in the MzS line and is plotted for each compound (A, closed circles). Mz (A, open circle) serves as the reference drug. Compounds were categorized arbitrarily into three groups to highlight their functional properties. In (B), resistance ratios for G. lamblia 713 (closed circles) and G. lamblia 106 (open circles) are plotted against the average antimicrobial activity against four Mz-sensitive lines for each drug, using the pEC50 values shown in Tables 2–4.