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. Author manuscript; available in PMC: 2010 Jul 9.
Published in final edited form as: J Med Chem. 2009 Jul 9;52(13):4038–4053. doi: 10.1021/jm900356n

Figure 5.

Figure 5

Relationship of redox potential and antigiardial activity and selectivity for new 5-NI compounds. The redox potential in DMSO (E1/2) of each new 5-NI was plotted against resistance ratios (A), overall antigiardial activity (B), and selectivity ratio relative to HeLa cells (C). For compounds with limited aqueous solubility, the data points represent the ratio of EC50 and the highest test concentration (100 μM) and thus the minimum rather than exact selectivity ratio (closed triangles in C). Mz (open circles) is shown in all panels as the reference drug.