Table 1.
Synthesis of 2-Ethenyl Derivatives of 5-NI by Aldol Condensation
 | |||||||
|---|---|---|---|---|---|---|---|
| entry | aldehyde | product | yield (%) | entry | Aldehyde | product | yield (%) |
| 1 | Benzaldehyde |
 5 |
20 | 15 | 3-fluoro-benzaldehyde |
 19 |
13 |
| 2 | 2-methyl-benzaldehyde |
 6 |
23 | 16 | 3-methoxy-benzaldehyde |
 20 |
32 |
| 3 | 3-methyl-benzaldehyde |
 7 |
42 | 17 | 4-trifluoro-methoxy-benzaldehyde |
 21 |
14 |
| 4 | 4-methyl-benzaldehyde |
 8 |
22 | 18 | 2,3,4-trimethoxy-benzaldehyde |
 22 |
16 |
| 5 | 2,4,6-trimethyl-benzaldehyde |
 9 |
29 | 19 | 4-diethoxy-methyl-benzaldehyde |
 23 |
24 |
| 6 | 2-bromo-benzaldehyde |
 10 |
20 | 20 | 2-biphenyl-carbaldehyde |
 24 |
21 |
| 7 | 3-bromo-benzaldehyde |
 11 |
19 | 21 | 1-napthyl-aldehyde |
 25 |
28 |
| 8 | 4-bromo-benzaldehyde |
 12 |
72 | 22 | 2-napthyl-aldehyde |
 26 |
19 |
| 9 | 2-chloro-benzaldehyde |
 13 |
24 | 23 | piperonal |
 27 |
31 |
| 10 | 3-chloro-benzaldehyde |
 14 |
19 | 24 | 1-methyl-imidazole-2-carbaldehyde |
 28 |
77 |
| 11 | 4-chloro-benzaldehyde |
 15 |
15 | 25 | furan-2-carbaldehyde |
 29 |
53 |
| 12 | 2,4-dichloro-benzaldehyde |
 16 |
15 | 26 | 2-thiophene-carbaldehyde |
 30 |
23 |
| 13 | 2-iodo-benzaldehyde |
 17 |
20 | 27 | 3-thiophene-carbaldehyde |
 31 |
22 |
| 14 | 3-iodo-benzaldehyde |
 18 |
19 | ||||