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. 2009 Jul 21;587(Pt 18):4393–4404. doi: 10.1113/jphysiol.2009.176321

Figure 2. Src inhibition blocks the apoptotic K+ current surge.

Figure 2

A, representative whole-cell currents from cortical neurons recorded under control, DTDP (30 μm), PP2 (10 μm), DTDP + PP2, PP3 (10 μm), and DTDP + PP3 treatment conditions. Currents were obtained 3 h post-injury and evoked by sequential 10 mV voltage steps to +80 mV from a holding potential of −80 mV. Calibration: 5 nA, 25 ms B, mean ±s.e.m. current densities from cortical neurons recorded under control (n= 13), DTDP (n= 14), DTDP + PP2 (n= 10), PP2 (n= 10), PP3 (n= 10), and DTDP + PP3 (n= 10) treatment conditions. K+ currents were evoked by a single voltage step to +10 mV from a holding potential of −80 mV and normalized to cell capacitance. (***P < 0.001, *P < 0.05; ANOVA/Bonferroni).