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. 2009 Aug 3;587(Pt 18):4523–4541. doi: 10.1113/jphysiol.2009.177238

Figure 4. Q–V relationship of WT (blue) and KO (red) fibres.

Figure 4

A, KO data was well fitted by a single Boltzmann function with parameters of Qmax= 37.3 nC μF−1, Vhalf=−25.8 mV and k= 12.6; n= 11 fibres. A single Boltzmann function did not accurately fit the WT data. B, based on the second, temporally delayed component of charge movement seen in WT, but not KO fibres, a double Boltzmann fit was applied to the WT data using fixed KO parameters for the first Boltzmann function and free values for the second component. This double Boltzmann function very accurately fitted the WT data. The second component, analogous to the theoretically derived difference component, had Boltzmann parameters of Qmax= 15.2 nC μF−1, Vhalf=−13.0 mV and k= 4.8; n= 12 fibres. A curve with these parameters is simulated in the WT – KO (green) trace.