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Phosphorylation of eIF-2α by AG490. (A) Temporal profile of phosphorylation of eIF-2α and induction of GADD153 (GADD) by AG490 (50 µM). The cells were treated with AG490 for the indicated times, and then Western blot analysis was performed. (B) Cells were treated with an ER stress inducer dithiothreitol (DTT, 3 mM) for the indicated times, and protein levels of gp130, peIF-2α and GADD153 were analyzed by Western blotting.
