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. 2000 Aug 22;97(18):10044–10049. doi: 10.1073/pnas.160245097

Figure 2.

Figure 2

Expression of Bmp4 is absent from distal chick mandibular epithelium. (a) In the stage 27 chick mandible, Bmp4 is expressed in mesial oral epithelium and does not extend distally to the region of epithelial thickening (bracketed). (b) In contrast, in E11.5 mouse mandible, Bmp4 expression extends distally to the molar tooth-forming region (bracketed). (c and d) BMP4-soaked beads can induce Msx1 and Msx2 expression in stage 27 chick mandibular mesenchyme. BSA-soaked beads do not induce Msx1 or Msx2 expression (not shown). (e) BMP4 bead (Right) represses endogenous Pax9 expression in day 5 chick mandibular explants, whereas BSA bead (Left) does not. (f) FGF8 bead (Right) activates Pax9 expression in de-epithelialized day 4.5 chick mandibular explants, whereas BSA bead (Left) does not.